Monaróir & Monarcha púdar Vardenafil HCL
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Vardenafil púdar HCL

Rátáil: Catagóir:

Is é AASraw an monaróir gairmiúil púdar amh hidreaclóiríd Vardenafil íon a bhfuil saotharlann neamhspleách agus monarcha mhór mar thacaíocht aige, déanfar an táirgeadh ar fad faoi rialachán CGMP agus córas rialaithe cáilíochta inrianaithe. Tá an córas soláthair cobhsaí, tá orduithe miondíola agus mórdhíola inghlactha. Fáilte chuig ordú ó AASraw!

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Hidreaclóiríd Vardenafil Físeán púdar-AASraw

Raw HCL Vardenafil Púdar Buncharachtair

Ainm: Púdar hidreaclóiríd Vardenafil (Levitra)
CAS: 224785-91 5-
Foirmle Mhóilíneach: C22H19N3O4
Meáchan Móilíneach: 389.4
Pointe Meáchain: 298 300-° C
Teocht Stórála: 20ºC
Dath: Bán Púdar

What is Vardenafil hydrochloride Powder?

Vardenafil hydrochloride powder,also called vardenafil HCL powder,is one of a enzyme phosphodiesterase type 5 (PDE5) inhibitors.This enzyme is responsible for the degradation of cyclic guanosine monophosphate (cGMP),a molecule that plays a crucial role in the erectile process.

During sexual arousal,nitric oxide is released in the erectile tissue of the penis (corpus cavernosum),which then stimulates the enzyme guanylate cyclase.This enzyme increases levels of cGMP,which in turn relaxes the smooth muscle cells in the corpus cavernosum.The relaxation of these muscles allows more blood to flow into the penis,leading to an erection.

By inhibiting PDE5,AASraw vardenafil hydrochloride powder prevents the breakdown of cGMP,thus maintaining higher levels of this molecule and prolonging its effects.This results in sustained muscle relaxation and blood flow,thereby aiding in the maintenance of an erection during sexual activity.

How does Vardenafil hydrochloride Powder work?

Vardenafil hydrochloride powder works as a selective inhibitor of an enzyme called phosphodiesterase type 5 (PDE5).Here’s a step-by-step guide to how it works:

①Sexual stimulation triggers the release of nitric oxide in the corpus cavernosum,a region of the penis.

②This nitric oxide triggers an enzyme called guanylate cyclase to convert guanosine triphosphate (GTP) into cyclic guanosine monophosphate (cGMP).

③The cGMP causes the smooth muscles in the corpus cavernosum to relax,which allows the blood vessels to dilate.

④The dilation of the blood vessels increases blood flow into the penis,leading to an erection.

⑤Normally,the enzyme PDE5 breaks down cGMP,ending the erection.Vardenafil hydrochloride works by inhibiting the action of PDE5,thus allowing the cGMP to remain longer and prolong the erection.

⑥Ultimately,vardenafil hydrochloride enhances and sustains the biological process that leads to an erection in response to sexual stimulation.

It’s important to understand that vardenafil hydrochloride does not cause an erection directly.Instead,it enhances the body’s natural response to sexual stimulation.Also,it’s important to buy vardenafil hydrochloride powder from reliable supplier like AASraw,which have supplied pure verdenafil hcl powder for many years.

Vardenafil VS.Avanafil VS.Tadalafil VS.Sildenafil

The four most common PDE5 inhibitors on the market are sildenafil,tadalafil,vardenafil,and avanafil.These four medications are all PDE5 inhibitors and are the first line of treatment for ED.However,the chemical molecular structures of these four medications differ,resulting in various chemical and physical actions.As a result,their absorption,distribution,metabolism,and excretion in the body varies,as do their curative effects.

Coscóir PDE5 Tosú Gníomh Tmax (h) Cmax (ng/ml) T1/2 (h) Duration  (h) Main Adverse Reactions
sildenafil 30 nóiméad-1 uair an chloig 0.8-1 560 2.6-3.7 4 Headache,facial flushing,indigestion,nasal congestion,dizziness,abnormal vision
Vardenafil 15 min 0.9 200 3.9 8 Headache,facial flushing,indigestion,nasal congestion,dizziness,abnormal vision
Tadalafil 1h 2 378 17.5 36 Headache,facial flushing,indigestion,nasal congestion,dizziness,no visual abnormalities
Avanafil 10-15 min / > 1000 3-5 6-8 Headache,facial flushing,indigestion,nasal congestion,dizziness (less frequent compared to others)

Nóta:

Tmax = time to reach maximum plasma concentration

Cmax = maximum plasma concentration

T1/2 = half-life

This table summarizes the pharmacokinetic characteristics of the four PDE5 inhibitors discussed.It’s always important for healthcare providers to consider these differences when prescribing these medications,and patients should always use these medications under the supervision of a doctor.Moreover,buying vardenafil hcl powder from a trusted supplier such as AASraw assures you receive a product of excellent quality and purity.AASraw ,as a professional vardenafil hcl powder supplier,can supply vardenafil hydrochloride powder with high quality all over the world.

How to choose PDE5 inhibitors?

Choosing the right PDE5 inhibitor can depend on a variety of factors,including the patient’s overall health,the presence of other conditions,their lifestyle,and their individual response to medication.Here is a general guide to choosing a PDE5 inhibitor for reference,but remember to always consult with a healthcare provider to make the best choice for individual needs.

Patient Condition Recommended PDE5 Inhibitor Cúis
Desire for fast onset time Avanafil Fastest onset among the PDE5 inhibitors
Middle-aged and elderly with ED and chronic diseases (hypertension,hyperlipidemia) sildenafil Average pharmacokinetic parameters,less stimulation to the body
Middle-aged and elderly with ED and vascular endothelial dysfunction (e.g.diabetes) Tadalafil Long duration of action,can improve vascular endothelial function and urinary tract symptoms over time
Middle-aged and elderly with ED,no vascular diseases Vardenafil Mild effect,quick onset,low bioavailability,few adverse reactions
Middle-aged and elderly with ED,vascular endothelial dysfunction,sildenafil ineffective Avanafil High blood concentration,strong effect
Young and middle-aged with ED,no obvious organic etiology sildenafil Effective for ED caused by psychological factors
Abnormal visual function and ED Tadalafil No visual abnormalities among adverse reactions
Postprandial medication preference Avanafil,Vardenafil Absorption rate not easily affected by food

Notes:This information about PDE5 inhibitors is provided for general informational purposes only and does not constitute medical advice.The choice of a PDE5 inhibitor should always be made in consultation with a healthcare provider who can take into account the individual’s overall health,other medications being taken,and the specific nature and severity of the erectile dysfunction.While these medications can be effective in treating erectile dysfunction,they also have potential side effects and risks,and they are not suitable for everyone.Certain health conditions and other medications may interact with PDE5 inhibitors,leading to potentially serious adverse effects.Always seek the advice of a healthcare provider for any questions you may have regarding a medical condition.

Dosage and administration of Vardenafil hydrochloride Powder for reference

The dosage of vardenafil HCL powder may vary depending on the individual’s health,response to treatment,and other medications they may be taking.Here are general recommendations,but it is essential to follow your healthcare provider’s specific instructions.

Caighdeán dose for erectile dysfunction

The recommended starting dose of vardenafil is 10 mg,taken orally approximately 60 minutes before sexual activity.The dose may be increased to a maximum of 20 mg or decreased to 5 mg,based on individual efficacy and tolerability.The maximum recommended dosing frequency is once per day.

Othair le moderate hepatic impairment

For patients with moderate hepatic impairment (Child-Pugh B),a starting dose of 5 mg of vardenafil is recommended.The maximum dose in patients with moderate hepatic impairment should not exceed 10 mg.

Othair le sriamh realadh impairment

For patients with severe (CLcr <30 mL/min) renal impairment,a starting dose of 5 mg of vardenafil is recommended.

Patients on stábla alpha-bloosely tleiripe

The recommended starting dose of vardenafil for patients receiving stable alpha-blocker therapy is 5 mg.

Othair le concomitant use of CYP3A4 inhibitors

For patients taking potent CYP3A4 inhibitors (such as ketoconazole,itraconazole,ritonavir,indinavir,saquinavir,and atazanavir),an initial dose of 5 mg vardenafil should not be exceeded.

nótaí

It is important to note that sexual stimulation is required for a response to treatment.Vardenafil does not increase sexual desire and will not produce an erection without sexual stimulation.Buying vardenafil HCL powder from a reliable supplier can ensure that you are receiving a high-quality product that will help achieve the best efficacy for its intended use.AASraw aims to supplying high quality vardenafil hcl powder worldwide under CGMP regulation.If you have needs,AASraw is a great choice for purchasing vardenafil hcl powder.

Where to buy Vardenafil hydrochloride Powder?

Vardenafil hydrochloride powder can be purchased from a variety of online suppliers that specialize in selling pharmaceutical ingredients.When deciding to buy from an online supplier,it is important to verify that they are a reputable source,given the importance of the quality and purity of the product for health applications.Ensure the seller provides product specifications and quality assurance documents,such as a Certificate of Analysis.

If you’re seeking a reliable source for purchasing vardenafil powder,AASraw may be a suitable option.AASraw is a company that offers a wide range of pharmaceutical grade raw materials,including vardenafil powder.Their products are typically used by laboratories and research institutions for the development and production of various health products.

Raw HCL Vardenafil Tuarascáil Tástála Púdar-HNMR

Púdar Hidreaclóiríd Vardenafil HNMR

Cad é HNMR agus Cad a insíonn speictream HNMR duit? Is teicníocht anailíseach ceimice é speictreascópacht um Athshondais Mhaighnéadach Núicléach (NMR) a úsáidtear i rialú cáilíochta agus taighde chun ábhar agus íonacht sampla a chinneadh chomh maith lena struchtúr móilíneach. Mar shampla, is féidir le NMR anailís chainníochtúil a dhéanamh ar mheascáin ina bhfuil comhdhúile aitheanta. Maidir le comhdhúile anaithnid, is féidir NMR a úsáid chun meaitseáil le leabharlanna speictreach nó chun an bunstruchtúr a bhaint amach go díreach. Nuair atá an bunstruchtúr ar eolas, is féidir NMR a úsáid chun comhfhoirmiú móilíneach i réiteach a chinneadh chomh maith le staidéar a dhéanamh ar airíonna fisiceacha ag an leibhéal móilíneach, mar shampla malartú comhfhoirmiúil, athruithe céime, tuaslagthacht agus idirleathadh.

Púdar hidreaclóiríd Vardenafil (224785-91-5) - COA

Púdar hidreaclóiríd Vardenafil (224785-91-5) - COA

Conas Púdar Vardenafil HCL a cheannach ó AASraw?

❶ Chun teagmháil a dhéanamh linn tríd ár gcóras fiosrúcháin ríomhphoist, nó d'uimhir whatsapp a fhágáil chugainn, déanfaidh ár n-ionadaí seirbhíse custaiméara (CSR) teagmháil leat i 12 uair an chloig.

❷ Chun do chainníocht agus do sheoladh fiosraithe a sholáthar dúinn.

❸ Soláthróidh ár CSR an luachan, an téarma íocaíochta, an uimhir rianaithe, na bealaí seachadta agus an dáta teachta measta (ETA) duit.

❹ Íocaíocht déanta agus seolfar na hearraí amach i gceann 12 uair an chloig.

❺Earraí faighte agus tuairimí a thabhairt.

Tagairt

[1] Aversa A,Pili M,Francomano D,Bruzziches R,Spera E,La Pera G,Spera G (July 2009). “Effects of vardenafil administration on intravaginal ejaculatory latency time in men with lifelong premature ejaculation”Iris Idirnáisiúnta um Thaighde Impotence. 21 (4):221–7. 

[2] Schools of Pharmacy (Glen L.Stimmel,D.,and Mary A.Gutierrez,Pharm.D.) and Medicine (Glen L.Stimmel,Pharm.D.),University of Southern California,Los Angeles,California. “Counseling Patients About Sexual Issues:Drug-Induced Priapism”.Medscape.Retrieved 2010-12-06.

[3] “New erectile dysfunction treatment Staxyn approved in the U.S.– Pharmaceutical Processing”com.2010-06-21.Archived from the original on 2012-04-06.

[4] Tucker J,Fischer T,Upjohn L,Mazzera D,Kumar M (October 2018). “Unapproved Pharmaceutical Ingredients Included in Dietary Supplements Associated With US Food and Drug Administration Warnings”Oscailte Líonra JAMA. 1(6): 

[5] Lepor H,Lepor NE,Hill LA,Trohman RG (2008). “The QT Interval and Selection of Alpha-Blockers for Benign Prostatic Hyperplasia”. Reviews in Urology. 10 (2):85–91.


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